Ozempic Side Effects in Males vs. Females

Ozempic (semaglutide), a GLP-1 receptor agonist approved for type 2 diabetes and widely prescribed off-label for weight loss, has become one of the most discussed medications in the U.S. As its use expands across age groups and genders, researchers and clinicians are examining whether side effects differ between males and females—and what those differences mean for patient care and litigation.

This article explores the most common and emerging side effects of Ozempic, how they vary by sex, and what patients should know before starting or continuing treatment.

Are Side Effects Gender-Specific?

While Ozempic’s core side effects—nausea, vomiting, diarrhea, and fatigue—are common across all users, recent studies suggest that females may experience certain reactions more frequently or more severely than males.

Key Findings:

  • A 2020 South Korean study found that females using GLP-1 drugs reported side effects twice as often as males, including:
    • Headaches (8x more common)
    • Dizziness (3x more common)
    • Vomiting (4x more common)
  • A 2022 semaglutide study showed that 75% of participants were female, and they reported higher rates of gastrointestinal symptoms
  • RAND’s 2025 national survey found that women aged 50–64 are the most frequent users of GLP-1 drugs, and nearly half reported nausea, while one-third reported diarrhea

Side Effects More Common in Females

Females appear to be more susceptible to certain Ozempic-related complications, possibly due to hormonal, anatomical, or metabolic differences.

Gastrointestinal Symptoms

  • Nausea, vomiting, bloating, and constipation are more frequently reported by females
  • Females are generally more prone to GI disorders, which may amplify Ozempic’s effects

Headaches and Dizziness

  • These symptoms are reported at significantly higher rates in female users
  • Hormonal fluctuations may contribute to increased sensitivity

Pelvic and Sexual Health Changes

  • Rapid weight loss from Ozempic has been linked to vaginal laxity, dryness, and pelvic floor weakening in some women
  • These effects may lead to discomfort during intercourse, urinary incontinence, or pelvic organ prolapse

Side Effects More Common in Males

While fewer studies focus on male-specific reactions, anecdotal reports and early data suggest some unique trends:

Gastrointestinal Symptoms

  • Males report nausea and vomiting less frequently than females
  • Diarrhea and appetite suppression are still common but less severe

Sexual Health Changes

  • Some men have reported a phenomenon dubbed “Ozempic penis,” describing perceived increases in size or firmness. Experts caution this may be due to weight loss and improved blood flow, not a direct pharmacological effect

Muscle Loss and Fatigue

  • Both sexes may experience muscle loss, but males with higher baseline muscle mass may notice more pronounced fatigue or strength decline during rapid weight loss

Why These Differences Matter

Understanding sex-based differences in Ozempic side effects is critical for:

  • Personalized prescribing: Adjusting dosage or monitoring based on patient sex and medical history
  • Litigation and intake: Identifying patterns in adverse event claims for mass torts
  • Patient education: Helping users anticipate and manage side effects more effectively

What Patients Should Do

If you’re experiencing side effects from Ozempic:

  • Track symptoms and note their severity and duration
  • Consult your healthcare provider before discontinuing the drug
  • Report adverse events to the FDA’s MedWatch program
  • Preserve medical records if considering legal action

Why Contact The Law Office of Melinda J. Helbock

At The Law Office of Melinda J. Helbock, A.P.C., we are actively investigating Ozempic-related injury claims, including those involving gender-specific side effects. Our firm offers:

  • Decades of experience in pharmaceutical litigation
  • Compassionate, confidential consultations
  • Proven results in securing compensation for injured patients

If you or a loved one suffered serious side effects from Ozempic, contact our San Diego office today. We’ll help you understand your rights and pursue justice.

References

  • Healthline. (2025). Ozempic side effects in females vs. males. Retrieved from https://www.healthline.com/health/drugs/ozempic-side-effects-in-females
  • KTVZ. (2025, February 25). Are Ozempic side effects more common in females? Retrieved from https://ktvz.com/stacker-science/2025/02/25/are-ozempic-side-effects-more-common-in-females/
  • SciTechDaily. (2025, August 6). Nearly 12% of Americans have used Ozempic or similar medications. Retrieved from https://scitechdaily.com/nearly-12-of-americans-have-used-ozempic-or-similar-medications/
  • LADbible. (2025, August 18). Worrying sexual impact ‘Ozempic vulva’ could have as women report same issue. Retrieved from https://www.ladbible.com/news/health/ozempic-side-effects-females-vulva-women-097174-20250818
  • Health and Me. (2024, December 7). Does Ozempic have different side effects on women and men? Retrieved from https://www.healthandme.com/health-wellness/does-ozempic-have-different-side-effects-on-women-and-men-article-151105103